منابع مشابه
Mechanisms of trauma-induced coagulopathy.
The identification and management of coagulopathy is a critical component of caring for the severely injured patient. Notions of the mechanisms of coagulopathy in trauma patients have been supplanted by new insights resulting from close examination of the biochemical and cellular changes associated with acute tissue injury and hemorrhagic shock. Acute intrinsic coagulopathy arising in severely ...
متن کاملAcute traumatic coagulopathy and trauma-induced coagulopathy: an overview
Hemorrhage is the most important contributing factor of acute-phase mortality in trauma patients. Previously, traumatologists and investigators identified iatrogenic and resuscitation-associated causes of coagulopathic bleeding after traumatic injury, including hypothermia, metabolic acidosis, and dilutional coagulopathy that were recognized as primary drivers of bleeding after trauma. However,...
متن کاملAcute Traumatic Coagulopathy: an Endogenous Precursor of Trauma-induced Coagulopathy
Recent findings Trauma causes an acute disruption of the equilibrium between all components of haemostasis (coagulation, anticoagulation, fibrinolysis, platelets and endothelium). In patients with a combination of severe tissue damage and systemic hypoperfusion, this will progress rapidly to an endogenous coagulopathy that is independently associated with worse outcomes. New discoveries of the ...
متن کاملTrauma Induced Coagulopathy: Prevention and Intervention
Trauma is associated with 1 in 10 deaths, with approximately 5.8 million mortalities annually worldwide [1]. Significant traumatic bleeding is associated with a poor outcome, with a total mortality of 30%, and is the leading cause of preventable death. Trauma and massive transfusion are associated with trauma induced coagulopathy (TIC), which triggers secondary hypoperfusion, dilutional coagulo...
متن کاملTranexamic acid and trauma-induced coagulopathy
Tranexamic acid (TXA) is a synthetic derivative of the amino acid lysine that inhibits fibrinolysis by blocking the interaction of plasminogen with the lysine residues of fibrin. Historically, TXA is commonly used for reduction of blood loss in perioperative situations, while recently it has attracted attention for clinical use in the trauma field. In 2010, the Clinical Randomization of an Anti...
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ژورنال
عنوان ژورنال: Hämostaseologie
سال: 2019
ISSN: 0720-9355,2567-5761
DOI: 10.1055/s-0039-1677853